Anticonvulsants as Calcium Antagonists in Mood Stabilization

Posted by Natasha Tracy | Mar 20, 2010

This is a paper I wrote for a psychology course I am taking so the level of discourse is quite high, sorry about that. I promise though, it is comprehensible. What I’m basically talking about is calcium-channel blockers and other calcium antagonists (they turn calcium down). This refers to calcium in your brain and not calcium in your blood.

Mood Stabilizers and Bipolar Disorder

Because inadequate response, poor compliance, chronic recurring symptoms, and functional disability are constant challenges is the treatment of bipolar disorder, (Gitlin, 2006) efforts have been made to search out new mood stabilizing medication and determine new methods of action. There has been an effort to treat bipolar disorder with a class of medication termed “mood stabilizers”, most notably consisting of some anticonvulsants (also known as antiepileptics) in addition to the traditional lithium.[1] While anticonvulsants are widely used in the treatment of mood disorders, their method of action in mood stabilization is mostly unknown.[2] Recent research has indicated that disrupted calcium homeostasis is present in bipolar disorder, and that anticonvulsants and lithium effect calcium channels and concentration in the brain (Amann, 2005). The mood-stabilizing effects of calcium channel blockers like Nimodipine (Levy, 2000) further add to the evidence that calcium antagonism is useful in the treatment of bipolar disorder. I will show that these “mood stabilizers”, anticonvulsants, stabilize mood in bipolar disorder, at least partially, through their ability to act as calcium antagonists.

Caffeine and Mental Illness and Caffeine Disorders

Posted by Natasha Tracy | Feb 21, 2010

Caffeine is the world’s most popular psychoactive substance. So many of us love it a la Starbucks, Tim Hortons or just out or our home coffee machine. Me, I love coffee and I’m a fan of caffeine too. Coffee’s the nectar of the gods and nothing will convince me otherwise.

It seems though, caffeine can actually hurt you. I know, I never thought my beloved coffee could harm me, but I suppose anything that you abuse, will abuse you back. So, here is everything you ever needed to know about caffeine, caffeine disorders and caffeine and mental illness but were afraid to ask.

They Liked Me, Again!

Posted by import_user | Oct 28, 2009

The kind people at PsychCentral have voted me one of the top ten bipolar blogs again this year. I’m honored. Thanks. Here’s what they have to say: Caught in my Bipolar Burble. She’s been blogging since 2003 and is...

Calcium Channel Blockers (Verapamil) and Bipolar

Posted by Natasha Tracy | Oct 28, 2009

For anyone who is wondering, I am currently trying a calcium channel blocker to control my mood. This is a last-line treatment really as there are conflicting reports as to whether it works at all, but when you’re me,...

Causes of Mood Disorders – Serotonin, Dopamine, Norepinephrine

Posted by Natasha Tracy | Jul 26, 2009

Today, I was watching a Comcast On Demand program about the causes of bipolar. I thought I’d watching and see how ridiculous it was because obviously, no one knows the cause of bipolar disorder.

However, the spot had some interesting information on the brain, neurotransmitters and bipolar disorder, which I then transcribed so I could share it with you. (Yes, I really did transcribe the whole thing.)

It’s in fairly layperson terms, so give it a look. At the bottom is a bit more information about dopamine, norepinephrine, and serotonin. This, unfortunately, is not in layperson terms, but is interesting nonetheless.

Diet and Depression / Bipolar

Posted by Natasha Tracy | Jul 20, 2009

I’ve written about this before, but due to the amount of misinformation on the internet on this topic, I feel compelled to write about it again.

Omega-3 and Depression
Folic Acid and Depression
Low-Carb Diets and Mood

Now, first off, I do not believe you can cure depression or bipolar using diet. Let me be clear, people who tell you this are mostly flakes. There are ways though that you can possibly improve your treatment plan using dietary components.

Physiological Causes of Depression – Surgeon’s General Report

Posted by Natasha Tracy | Jul 6, 2009

I like to think I know almost all there is to know about mood disorders, but I was pretty shocked when I read this:

The Surgeon’s General Report

Differential Diagnosis
Mood disorders are sometimes caused by general medical conditions or medications. Classic examples include the depressive syndromes associated with dominant hemispheric strokes, hypothyroidism, Cushing’s disease, and pancreatic cancer (DSM-IV). Among medications associated with depression, antihypertensives and oral contraceptives are the most frequent examples. Transient depressive syndromes are also common during withdrawal from alcohol and various other drugs of abuse. Mania is not uncommon during high-dose systemic therapy with glucocorticoids and has been associated with intoxication by stimulant and sympathomimetic drugs and with central nervous system (CNS) lupus, CNS human immunodeficiency viral (HIV) infections, and nondominant hemispheric strokes or tumors. Together, mood disorders due to known physiological or medical causes may account for as many as 5 to 15 percent of all treated cases (Quitkin et al., 1993b). They often go unrecognized until after standard therapies have failed.

(bold mine)

I’m shocked. No one ever mentioned anything about birth control pills to me and I’ve been on them for years. YEARS. This is yet another reason why doctors so often get on my bad side.

This quote was taken from the Mental Health: A Report of the Surgeon General. The whole report is a good read, but very long. It’s everything you wanted to know but didn’t know you needed to ask.

I’m disgusted.

AstraZeneca Accused of Hiding Seroquel Dangers

Posted by Natasha Tracy | May 25, 2009

AstraZeneca plays hot potato with Seroquel side effects. Here are the highlights from the article (bold and italic text added by me):AstraZeneca E-mails Show Debate on Seroquel RisksAssociated Press – May. 20, 2009TRENTON,...

More on rTMS and VNS and MRI

Posted by Natasha Tracy | Jan 18, 2009

I frequent poster, Herb, has introduced more information on the rTMS with VNS topic. Some doctors are saying it is possible. Additionally, if you read the whole thread, someone corrects me and notes that MRIs are possible with a...