Category: treatment issues

Antidepressant Comparison: Are Pristiq and Effexor the Same?

Posted by Natasha Tracy | Jun 18, 2010

Does Pristiq Just Serve to Extend the Effexor Patent?

If you live in the US, you’ve probably seen all the commercials for the new and pastel-pink-coloured antidepressant Pristiq. (Yes, prescribed for depression.) Pristiq is new and has a huge marketing push behind it and is a selective serotonin norepinephrine reuptake inhibitor (SNRI) antidepressant. In other words, it’s an antidepressant that works on both serotonin and norepinephrine neurotransmitters. It is not the only antidepressant to do this, but SNRIs are a smaller class of drugs than those that just effect serotonin alone (like Prozac). (Although admittedly, there seems to be a suspicious number of SNRI antidepressants in development.)

Pristiq and Effexor Are Almost the Same Drug

What you might not know, is the same company that makes the drug Pristiq (Wyeth) also makes Effexor, which is an almost identical antidepressant, and Effexor has recently become available in generic form (Venlafaxine). Pristiq, O-desmethylvenlafaxine, is actually the main metabolite of Effexor, venlafaxine hydrochloride.

This means that if you take Effexor, your body breaks it down into Pristiq and other chemicals. Yes, Pristiq and Effexor are almost the same drug.

Will ECT Work for Me? — Predictors of ECT Efficacy

Posted by Natasha Tracy | May 12, 2010

It would be nice to know ahead of time, if a treatment would work. Unfortunately, no one cal tell the future: not for cancer treatment and not for mental illness treatment like electroconvulsive therapy (ECT) either.

Will Electroconvulsive Therapy Work for Me?

But very smart people try to figure out what might predict the outcome of treatments. Especially treatments like ECT, a hotly debated, and much maligned treatment. That’s the good news. And the bad news.

In a retrospective chart review of depressive and bipolar patients in a Netherlands hospital, of those who received ECT, 65.8% met the standards for remission. The only predictor of response found was duration of index series.

Dimensional Diagnosis of Mental Illness

Posted by Natasha Tracy | Apr 23, 2010

There is a recognition among many of us crazies, as well as the professionals that treat us, that most of us do not simple fall into one camp – we’re bipolar with a hint of ADD; we have a borderline personality disorder with depressive and psychotic features; we suffer from schizo-affective disorder with post-traumatic stress disorder (PTSD) and addiction mixed in. Humans are complex, and their brains even more so.

My Depression Isn’t Your Depression

And what’s more, my depression isn’t like your depression. In fact, so much so, that using the same word is almost nonsensical. I sleep 15 hours a day, but you only sleep 3. I have a successful job, but no family or friends. You have neither but participate in online support groups 10 hours a day. I think about killing myself every day but you actually plan for it once a week. You never cry but I cry all the time. Are we the same? Am I more depressed than you, or less?

And things get more complicated when you compare personality disorders and bipolar and ADD and PTSD combined with comorbid conditions like addiction. And yet somehow we’re supposed to suss this all out, find a label, and a treatment that goes with it. That’s pretty tough.

Who Do You Trust for Mental Illness Medication Information?

Posted by Natasha Tracy | Apr 11, 2010

As you might have noticed, I’ve been writing about bipolar and mental illness for a really long time. Seven years in internet time is a lifetime or so.

I Write About and Research Mental Illness

And in all that time, in addition to the writing, I’ve been reading, or more commonly, researching mental illness. I’ve been looking up information on mental disorders, psychiatric medications, mental illness treatments, supplements and everything else of which you can think. This is because I like to be educated about my bipolar disorder and my healthcare and treatments. I often share that researched information because I think others should be educated about mental illness too. I strive to make anything I write accurate and provide links to reputable sources.

Who Do You Trust for Mental Illness Information?

But what information should you trust? Who should you trust for mental health information? Should you trust me, a random blogger? People on discussion groups? Information sites? Drug company sites? Doctor sites?

Pretty much, almost always, no.

Anticonvulsants as Calcium Antagonists in Mood Stabilization

Posted by Natasha Tracy | Mar 20, 2010

This is a paper I wrote for a psychology course I am taking so the level of discourse is quite high, sorry about that. I promise though, it is comprehensible. What I’m basically talking about is calcium-channel blockers and other calcium antagonists (they turn calcium down). This refers to calcium in your brain and not calcium in your blood.

Mood Stabilizers and Bipolar Disorder

Because inadequate response, poor compliance, chronic recurring symptoms, and functional disability are constant challenges is the treatment of bipolar disorder, (Gitlin, 2006) efforts have been made to search out new mood stabilizing medication and determine new methods of action. There has been an effort to treat bipolar disorder with a class of medication termed “mood stabilizers”, most notably consisting of some anticonvulsants (also known as antiepileptics) in addition to the traditional lithium.[1] While anticonvulsants are widely used in the treatment of mood disorders, their method of action in mood stabilization is mostly unknown.[2] Recent research has indicated that disrupted calcium homeostasis is present in bipolar disorder, and that anticonvulsants and lithium effect calcium channels and concentration in the brain (Amann, 2005). The mood-stabilizing effects of calcium channel blockers like Nimodipine (Levy, 2000) further add to the evidence that calcium antagonism is useful in the treatment of bipolar disorder. I will show that these “mood stabilizers”, anticonvulsants, stabilize mood in bipolar disorder, at least partially, through their ability to act as calcium antagonists.

Caffeine and Mental Illness and Caffeine Disorders

Posted by Natasha Tracy | Feb 21, 2010

Caffeine is the world’s most popular psychoactive substance. So many of us love it a la Starbucks, Tim Hortons or just out or our home coffee machine. Me, I love coffee and I’m a fan of caffeine too. Coffee’s the nectar of the gods and nothing will convince me otherwise.

It seems though, caffeine can actually hurt you. I know, I never thought my beloved coffee could harm me, but I suppose anything that you abuse, will abuse you back. So, here is everything you ever needed to know about caffeine, caffeine disorders and caffeine and mental illness but were afraid to ask.

Physiological Causes of Depression – Surgeon’s General Report

Posted by Natasha Tracy | Jul 6, 2009

I like to think I know almost all there is to know about mood disorders, but I was pretty shocked when I read this:

The Surgeon’s General Report

Differential Diagnosis
Mood disorders are sometimes caused by general medical conditions or medications. Classic examples include the depressive syndromes associated with dominant hemispheric strokes, hypothyroidism, Cushing’s disease, and pancreatic cancer (DSM-IV). Among medications associated with depression, antihypertensives and oral contraceptives are the most frequent examples. Transient depressive syndromes are also common during withdrawal from alcohol and various other drugs of abuse. Mania is not uncommon during high-dose systemic therapy with glucocorticoids and has been associated with intoxication by stimulant and sympathomimetic drugs and with central nervous system (CNS) lupus, CNS human immunodeficiency viral (HIV) infections, and nondominant hemispheric strokes or tumors. Together, mood disorders due to known physiological or medical causes may account for as many as 5 to 15 percent of all treated cases (Quitkin et al., 1993b). They often go unrecognized until after standard therapies have failed.

(bold mine)

I’m shocked. No one ever mentioned anything about birth control pills to me and I’ve been on them for years. YEARS. This is yet another reason why doctors so often get on my bad side.

This quote was taken from the Mental Health: A Report of the Surgeon General. The whole report is a good read, but very long. It’s everything you wanted to know but didn’t know you needed to ask.

I’m disgusted.