L-methylfolate as Antidepressant Enhancing Agent

I do a lot of psychopharmacology research reading. Like, a lot. I try to post things that I find interesting and not bore you with everything else. Similarly, I try to post things that are decently easy to read and understand. Today though, you have not gotten off so lucky, but the article is interesting.

What is L-Methylfolate?

L-methylfolate (MTHF) is a compound your body makes from folate (and the help of a few other things). Folic acid is the synthetic version of folate, available to take in supplemental form. Pregnant mothers generally take folic acid. As you would assume, taking more folic acid, will up the level of MTHF found in the brain.

The problem comes with an MTHF deficiency. This deficiency cannot necessarily be corrected by taking folic acid as some people genetically do not synthesize enough MTHF from folate from the diet or through supplements, moreover, there is some evidence to suggests that MTHF can “turn up” the efficacy of antidepressants even when no deficiency is present. It can also take many, many times the amount of folic acid to synthesize the amount of MTHF needed than would be found in the diet or available supplements. Anticonvulsants (mood stabilizers, like Lamictal and others) can also create a depletion in MTHF.

What Does This L-Methylfolate Stuff Mean?

The long story short is this, there is some evidence to suggest that taking MTHF supplements is warranted when antidepressants have either stopped working, or are not working at all. MTHF supplements are considered neither a drug, nor a food by the FDA (funny huh) but are still regulated and require a prescription.

This is really preliminary data there are all kinds of studies needed to bear out these findings, and my explanation above has been really simplified. But the really great thing about knowing about it is that it can help you, without causing the kind of side effects you typically see with pharmacological drugs. My doctor, who is seriously a no-nonsense woman made me aware of this, really respects the author of the article, and has given me a prescription for the stuff, whatever that’s worth. When you think about it, this actually makes a lot of sense. After being on anticonvulsants for years (like, eight of them) it’s not surprising that I’m deficient in a nutrient or two. This would explain why antidepressants just don’t seem to work in some people, and also seem to stop working after some time.

The article itself is good, but it’s extremely complicated and has so many chemical names in it it makes my brain hurt. There are pictures though. Kind of funny ones, I think. So, try to wade through the article, or just print out a copy and take it into your doctor and see what the say.

Article found here. Enjoy. (At least look at the diagrams. Steve there has a sense of humor.)


About Natasha Tracy

Natasha Tracy is an award-winning writer, speaker and consultant from the Pacific Northwest. She has been living with bipolar disorder for 18 years and has written more than 1000 articles on the subject.

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Find more of Natasha’s work in her new book: Lost Marbles: Insights into My Life with Depression & Bipolar. Media inquiries can be emailed here.