Struggling with antidepressants that just aren’t working? L-methylfolate (MTHF) might be the missing piece. This key nutrient helps your brain produce serotonin, dopamine, and norepinephrine—exactly what antidepressants target. But some people don’t make enough of it naturally. Could supplementing with MTHF boost your treatment? Find out what the research says, plus my thoughts on it.
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After looking at the future treatment approaches for treatment-resistant depression, I thought I’d share a bit more depression and bipolar research. New options offer hope for everyone who run the gamut of bipolar or depression treatments.
I try not to give medical advice here because I am not a doctor. But so many people ask me about this I felt I had to address getting off antidepressants without withdrawal. So many people with bipolar disorder (depression and others) need information about getting off psych meds and they are not getting it from their doctors.
This is the first in a three-part series:
If you live in the US, you’ve probably seen all the commercials for the new and pastel-pink-coloured antidepressant Pristiq. (Yes, prescribed for depression.) Pristiq is new and has a huge marketing push behind it and is a selective serotonin norepinephrine reuptake inhibitor (SNRI) antidepressant. In other words, it’s an antidepressant that works on both serotonin and norepinephrine neurotransmitters. It is not the only antidepressant to do this, but SNRIs are a smaller class of drugs than those that just effect serotonin alone (like Prozac). (Although admittedly, there seems to be a suspicious number of SNRI antidepressants in development.)
What you might not know, is the same company that makes the drug Pristiq (Wyeth) also makes Effexor, which is an almost identical antidepressant, and Effexor has recently become available in generic form (Venlafaxine). Pristiq, O-desmethylvenlafaxine, is actually the main metabolite of Effexor, venlafaxine hydrochloride.
This means that if you take Effexor, your body breaks it down into Pristiq and other chemicals. Yes, Pristiq and Effexor are almost the same drug.
Read MoreToday, I was watching a Comcast On Demand program about the causes of bipolar. I thought I’d watching and see how ridiculous it was because obviously, no one knows the cause of bipolar disorder.
However, the spot had some interesting information on the brain, neurotransmitters and bipolar disorder, which I then transcribed so I could share it with you. (Yes, I really did transcribe the whole thing.)
It’s in fairly layperson terms, so give it a look. At the bottom is a bit more information about dopamine, norepinephrine, and serotonin. This, unfortunately, is not in layperson terms, but is interesting nonetheless.
Read More‘Roud these parts lots of people are smoking lots of stuff that might not entirely be legal. Very common. Good climate for that sort of thing.I though, have always been of the opinion that marijuana makes depression worse...
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