Mixed Moods in Bipolar Disorder and Depression in the DSM-V

Posted by Natasha Tracy | Aug 16, 2011

The Diagnostic and Statistical Manual of Mental Disorders (DSM), the manual that defines all mental illness in the US, is being revised and a new version is due out in 2013. One of the proposed changes to the DSM is to the diagnosis of mixed moods. This change is being proposed by a mood disorders workgroup. It aims to reflect clinical practice where doctors already refer to a “mixed” mood that doesn’t officially meet the DSM criteria. (As I noted, mixed moods are only technically recognized in bipolar type 1.)

Changes to the mixed mood diagnosis will help people with bipolar 1, bipolar 2 and unipolar depression get better treatment.

Depressed People Who Take Antidepressants Do Better Long-Term – Part 2

Posted by Natasha Tracy | May 16, 2011

As I mentioned last week, it’s very difficult to measure long-term outcomes of depression treatment due to the confounding depression variables like severity of depression, duration of depression, number of depressions and so on.

In short, the sicker you are, the more depressed you are, the more likely it is you’ll get treatment.

Antidepressant Treatment Outcomes Long-Term, A Study

I discussed the basic outcomes of this study: The association between antidepressant use and depression eight years later: A national cohort study by Colman et al. which tries to take these variables into account.

Colman et al. showed those who took antidepressants had better depression treatment outcomes than those who didn’t, eight years later, once confounding variables were taken into consideration.

I’ll now point out the strengths and weaknesses of this study as well as some other interesting tidbits shown or cited in the study. Oh, and I’ll give my opinion on what it all means.

Depressed People Who Take Antidepressants Do Better Long-Term

Posted by Natasha Tracy | May 12, 2011

Recently the controversy over long-term outcomes of those who use psychotropic medication has flared up again. Some people argue depression/bipolar/mental illness patients do the same, or better, when they don’t take psychiatric medications long-term. However, the statistics they use to assert this claim are often faulty.

A study from Calgary, Alberta, Canada (yes, we do research up here too) has attempted to fix some of the bias seen in other long-term depression treatment outcome statistics. I’ll cut to the chase for you:

Over the course of eight years people with depression who took antidepressants had better outcomes.

Is There a Blood Test for Schizophrenia? – VeriPsych Tests for Schizophrenia

Posted by Natasha Tracy | Apr 18, 2011

Hot on the heels of my post about the neurobiological evidence for major depressive disorder comes this: the first blood-based diagnostic aid for schizophrenia.

Um, what’s that again?

The Neurobiology of Depression – Depression and the Brain

Posted by Natasha Tracy | Apr 15, 2011

Major Depressive Disorder: it isn’t just “all in your head.”

I have spent quite a bit of time in the last week looking at a paper: Pathophysiology of Depression: Do We Have Any Solid Evidence of Interest to Clinicians? By Gregor Hasler.

This paper discusses seven research areas relating to the neurobiology of major depressive disorder (MDD). In other words, it talks about the biological evidence of depression, mental illness. It discusses the strengths and weaknesses of biological theories of depression via evidence and aims to point out some of the reasons our current treatment isn’t as successful as it should be. The paper cites 88 other studies and was published in the Journal of World Psychiatry in 2010. It’s pretty educational.

Why Should I Continue to Fight the Pain of Depression for Another 40 Years?

Posted by Natasha Tracy | Mar 3, 2011

A commenter, Jessica, left a comment yesterday that so succinctly expresses what so many of us feel about depression, bipolar and mental illness, and continue to feel. The following is her comment and my response.

“when I just feel so sick and tired of fighting for what seems like nothing…what seems like a never ending battle…what seems like someone hitting me over the head with a two-by-four every two minutes, telling me it will never stop until the day I die, and then they explaining to me why I should continue to fight to live for another 40 years.”

Yes. I know.

Fighting the Pain of Depression

We fight to the death for millimeters when we really need a mile. I know.

Depression, Bipolar – Feeling Alone with a Mental Illness

Posted by Natasha Tracy | Jan 23, 2011

People with a mental illness feel alone.

Depression makes you feel alone. Depression makes you feel like you’re the only person that feels the pain and sadness that you do. Depression brings about negative spirals of thinking that convinces you that there is only darkness, nothingness and that you are utterly alone in the world. This loneliness is a symptom of depression.

Bipolar makes you feel alone too. Bipolar makes you think you are alone because no one else experiences the highs of mania and the lows of depression. Then there’s loneliness with Schizophrenia thanks to the rest of the world unfairly thinking you are violent and dangerous. And dissociative identity disorder convincing you that you are alone and that no one on the planet is as “crazy” as you.

In short, mental illness makes you feel alone and like there is no one else like you in the world.

Depression and Lack of Want, Desire

Posted by Natasha Tracy | Jan 19, 2011

Ah depression. Sucking, vaporizing, numbing black hole. A void where feeling used to be.

Last night I went out on a date. It was a girl I had connected with through a site online. Lovely girl. Smiling. Happy. There’s a picture of her taking another girl’s bikini top off with her teeth. Playful happiness.

And in person, she was, in fact, happy. Enthralled and entertained by me. She wanted to hear story after story. Captivated. Charmed. Her gaze burned into my flesh.

Most Notable Feeling in Depression is Nothingness. A Lack of Want.

And I felt, nothing.

Bipolar, Hypomania, Depression and Looking Crazy

Posted by Natasha Tracy | Jan 10, 2011

I can feel the post-depression-bounce-back hypomania beginning in my brain; not in my body, only in my brain. Hypomanic symptoms started yesterday evening. Things started seeming clear, perhaps just a little too clear, and certainly a little too fast. Bipolar fast. Gospel music (yes, oddly) played in my head intermittently while I guided an old tourist couple to the park, I drafted my upcoming novel, planned a conversation, and I investigated the fallen tree branch in the middle of the baseball field. Rapid fire thoughts, hypomanic thoughts, took over.