People with bipolar disorder are all-too-familiar with cycles – the moving from one mood to another – but not everyone knows that for some, moods can cycle ultra-ultra-rapidly. When a mood cycles last less than a day this is known as ultradian cycling. Ultradian cycling bipolar disorder is a very tough variant of bipolar disorder to treat and to live with.
About Ultradian Cycling
Please see this video below about ultradian cycling:
Ultradian Cycling Bipolar Disorder – Things to Know About Cycling and Bipolar
One thing to know about ultra-ultra-rapid cycling in bipolar disorder is that it’s very real. People with it are not “moody” per se. People with it are experiencing an illness that forces them to experience ever-shifting moods. I know what this is like. It’s real. It’s horrible. And remember, some people go through this every day.
Another thing to know is that antidepressants can cause cycling – in fact, can cause ultradian cycling – in those with bipolar disorder. This is important to know so that if you start experiencing rapid cycling after you start an antidepressant, you may want to get off of that antidepressant and see if it helps. (See here for how to get off an antidepressant while minimizing withdrawal.)
Rapid cycling variants of bipolar disorder can be harder to treat than standard bipolar disorder which has moods that last for months. This makes sense because if your mood lasts for months you really have a chance to get a handle on it and treat that specific mood. In other words, you know if you need to work things up or down because of where the mood is. If your mood is always shifting, you don’t need “up” or “down” you need level. That is much harder to target.
The spectrum from standard cycles to rapid cycles to ultra-rapid cycles to ultradian cycles is a bit arbitrary and there are no dead-set definitions for each. Plus, a person may waver between what length of cycles they have (I do that).
Rapid Cycling Bipolar Disorder in the Literature
According to Jim Phelps MD on PsychEducation.org, the following are posited after a literature review:
- An early age of onset is associated with a greater likelihood of rapid cycling.
- Episode frequency is a highly familial trait.
- Two recent studies reported that variations in the gene for brain derived neurotrophic factor (BDNF) are associated with rapid cycling, but not with bipolar disorder in general.
- In most patients, rapid cycling is a transient phenomenon; but it can persist for years in some. In general, the presence of rapid cycling is associated with greater treatment resistance. Even after it resolves, patients who have had it experience a more severe course of illness than those who did not have it.
So what have we learned? We’ve learned that rapid cycling (and certainly ultradian cycling) bipolar disorder sucks, on all levels.
Treating Ultradian Cycling Bipolar Disorder
Now, at this point, I would love to point you to some brilliant information that would address ultradian cycling using gold-standard research. Unfortunately, I can’t do that. I can’t do that because we don’t have enough research on rapid cycling in bipolar disorder to really say much that is definitive.
One thing I strongly suspect we can say, though, is that antidepressants are really bad for you if you rapid cycle. Here is an excellent case study about gradual antidepressant withdrawal and its effects on cycling. Both Gary Sachs MD, Director of the Harvard Bipolar Disorder Program, and Dr. Phelps agree on this point. (There’s more here.)
Something I strongly believe is that with rapid cycling versions of bipolar disorder you need to treat the cycling first and the mood second. I know this sounds kind of counter-intuitive but it’s not until you have a steady target (a specific mood) that you have anything to really aim for. You need to treat the cycling to get that target to sit still. Then you can start treating whatever mood symptoms are left. (This belief is based on personal experience and research, but feel free to disagree.)
One other thing to note about ultradian bipolar disorder treatment is that you might consider treating it in the same way that mixed states in bipolar disorder are treated. As I mentioned in the video above, ultra-ultra-rapid cycling moods can also be thought of as mixed moods as per the current diagnostic guidelines. Medications that are Food and Drug Administration approved to treat bipolar mixed moods are:
- Lithium
- Quetiapine (Seroquel)
- Olanzapine (Zyprexa)
- Lurasidone (Latuda)
More on mood stabilizers can be found here.
Additionally, something unique that might work for ultradian cycling treatment is dark therapy.
Dark Therapy as Ultradian Bipolar Disorder Treatment
Most people (and even some doctors) haven’t heard of dark therapy. It’s a pretty simple concept. Dark therapy involves controlling the dark and light hours of your day. It’s not the easiest thing to do (I’ve tried it).
In this case study, darkness was enforced from 6:00 p.m. until 8:00 a.m. the next morning. That’s 14 hours — that’s a lot of darkness. But this is critical because what you’re trying to do is reset your internal clock (circadian rhythm) and you kind of have to hit it with a baseball bat at first to get it to change. (You’ll note in the case study that after a few weeks it was lessened to 10 hours of enforced darkness per day.)
Unfortunately, there is very little research on dark therapy. Personally, I think if ultradian bipolar disorder is wreaking havoc on your life, it’s well worth trying (with your doctor’s say-so), but that’s just my opinion.
What anyone with bipolar disorder (rapid cycling or no) can take away from this, though, is that dark and light are very important in bipolar disorder and contribute to sleep cycles as well as mood cycles. For this reason, at the very least, you should be controlling your blue light intake in the evenings. (See here for more on light and darkness in bipolar disorder.)
Ultradian Bipolar Disorder Is Real – And Treatable
Just like with all versions of bipolar disorder, some people are going to be more successfully treated than others, that’s just the unfair fact of it. That said, ultradian bipolar disorder is treatable.
So if you’re suffering with moods that only last for hours, don’t give up and make sure and be open with your doctor about it. And if you need to, bring your doctor information about the above to help with your treatment. You can do this.
(While you’re here, you may also want to read something I wrote a few years ago: Dealing with Rapid Cycling Bipolar Moods in Everyday Life.)
Banner image by Giorgiogp2 [CC BY-SA 3.0 or GFDL], from Wikimedia Commons.
Image by Flickr user GalgenTX.
There is evidence that ultradian rapid cycling is caused by a defect in the gene that regulates calcium channelling. The treatment for this is the calcium channel blocker Nimodipine. I have just started on this and it is showing very positive results. Perhaps add a section on this to the blog.
I am glad you are feeling better. When did you start to notice improvement?
After a couple of weeks
Dear David what’s the dose of nimodipine?
Thank you for the video. I recognise the description of changing moods every few hours. I have been like that for over 20 years. Thinking life is heaven at 8.00, having hatefull thoughts at 10.30 and so on throughout most every day. But what I have noticed, is that the moods always follow my meals. I get hangry, eat, get tired, get happy, get hangry, eat, get tired… Does this sound familiar? I assumed, there was a problem in the way I respond to sugar and similar ingredients, so I left them out of my diet. That helps to keep the low moods less low, the high moods less high. But it is quite hard, as there are more things I can’t eat than things that I can. Also my moodswings still persist, just not as intense. I have no diagnosis nor a treatment. I have seen many doctors (e.g. specialists on diabetis) but none has had an idea of what I could do. Now I’m seeing a psychotherapist who mentionenend rapid cycling bipolar disorder. But is the foodconnection part of it?
Ultradian rapid cycling is completely real.it started with depression at the age of nine and ten, and it got worse every year as it progressed to the end of high school, which reached its peak. I am now twenty years old and I have become accustomed to it, but sometimes it really becomes unbearable. The main symptoms I have are irritability, severe restlessness, rapid mood swings, lack of concentration and impatience.
Dear Natasha, I saw your video today. Thank you. I am an ultra radian or mixed episode bipolar as diagnosed by my podcast and me. However I cycle from “normal” mood to deep depression which involves crying. Ability as an adjunct (2mg) to Prozac helped until I gained 40 lbs. As I write this I am exhausted by trying to hide my frequent crying. I am waiting for my podcast to return my call because I think topiramate May help. But thank you for reaching out with your video. Susan
I’m currently torn between whether I’m in a mixed state or flat out depression. I was diagnosed as BiPolar II rapid cycling, except when diagnosed my moods shifted in hours. I’m currently only on Lacmictal after being on Lexapro for years, then trintellix which did nothing, so I stopped antidepressants.
However, sometimes I’ll go through months and months of severe depression punctuated by mixed states.
I’m not sure I agree about how going off an antidepressant helps. I’ve found that very dangerous for me. For instance, I weaned myself off an antidepressant for the first time in years after being in the midst of a year long depressive period with mixed states. Now, I just feel nothing. I’ve flatlined into complete depression. The mixed states are gone. But now, I care about absolutely nothing, I feel nothing, and I’ve completely cut myself off from the world and am not functioning. Is that better on antidepressants? Yes. I’d rather be depressed with mixed states, than feel dead inside. Because now, I can’t even move.
So before any of you think about quitting your antidepressants, think twice. You might end up in the depressive phase face first, stuck, period. I’m currently on Lamictal as well, but I’m going back to antidepressants in addition to that. I’m trying Pristiq instead, so i hope that helps. My Lamictal helps with mixed states with the right antidepressant.
People, it could be you’re on the wrong one. Most suicides in BiPolar occur off meds period. I don’t care what this research says, I’ve experienced it in family members.
Maybe for some it could work, but I would think long and hard, and be closely monitored by experts and family.
I’ve quit antidepressants before also and the same thing happens. Then I end up back on them again. My biggest problem is I cant find an antipsychotic or mood stabilizer I can take. Lamictal causes a bad rash after 2 months when we increased the dose. It’s a daily struggle for me also. Sometimes I’m up and down like a yoyo all day long. Bipolar cycling sucks.
Oh, my gosh! I have tried every mood stabilizer over the past 20 years! I’m bipolar II and have been depressed for over two years following a seven month long manic cycle which caused severe financial problems and alienation of my best friends and family!
Now I’ve begun ultra-rapid cycling for about two weeks! My psychiatrist of 20 years has been working very hard with me. I’m happy then sad all going throughout the day! I’m exhausted! I’ll have suicidal thoughts then I’ll redecorate my living room!
The only antidepressant I’m on is Wellbutrin. I started with 75 mg per day, then 150, then back to 75 and now 37 1/2!
I also take Xanax and Seroquel.
Is mixed the sampe as rapid cycling?
My teenage daughter was recently diagnosed with bipolar 2 with ultra rapid cycling. It’s been a long, disheartening adventure. On one hand I’m happy to finally have a diagnosis. Apparently adolescents who suffer from bipolar often go towards rage (never knew that). Needless to say she was misdiagnosed multiple times. However on the other hand, the hospital led me to believe that medication works wonders. She’s on tegretol and it works okay (worked wonders for the first couple months but I’m wondering if it’s loosing it’s efficency). I’m wondering if you have any experience on this? How long did it take to find the right dose of meds? Is it the med itself or does rapid cycling occur even when someone is taking medication? Any advice on helping her cope with side effects? Thank you so much for posting this- unfortunately there aren’t many resources on ultra rapid cycling.
My husband is currently in hospital with bipolar mania. First experience of this was Nov 2017. And now. This dx is super new for us and I’m so scared. Especially since I have 2 young children with my husband. Now I’m worried they will have BP! I’m so stressed out. Everyone says the disease is manageable, but it seems to me to be unpredictable, scary, and highly stigmatized. I’m so sad.
Hi E,
What you’re feeling is completely normal. You’re in a very scary part of the illness process. Please know that we have all been there and you will get through it as will your husband. He is getting help, and that’s what really matters.
While bipolar disorder is unpredictable, scary and stigmatized, it _is_ manageable for most too. All of those things are true. You’re seeing the really dark parts right now but it won’t always be this dark.
What I highly recommend is that you do a bit more research on bipolar disorder (which you’re obviously already doing now). Knowledge is power.
I’d be remiss if I didn’t recommend my own book which has been very well received by those with bipolar disorder and their family members. You can get it here: https://www.amazon.com/Lost-Marbles-Insights-Depression-Bipolar/dp/1539409147/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1534864244&sr=1-1
Another great book is by Julie Fast and you can find it here: https://www.amazon.com/Loving-Someone-Bipolar-Disorder-Understanding/dp/1608822192/ref=pd_sim_14_4?_encoding=UTF8&pd_rd_i=1608822192&pd_rd_r=e4ac4846-b053-11e8-bcdb-932140fb8169&pd_rd_w=TVCBx&pd_rd_wg=EQ63e&pf_rd_i=desktop-dp-sims&pf_rd_m=ATVPDKIKX0DER&pf_rd_p=18bb0b78-4200-49b9-ac91-f141d61a1780&pf_rd_r=Y35Q119QBQ63VZY5AA9Q&pf_rd_s=desktop-dp-sims&pf_rd_t=40701&psc=1&refRID=Y35Q119QBQ63VZY5AA9Q
You can also check out the Mood Disorders Association of Ontario — https://www.mooddisorders.ca/ There are people and programs there that can help.
Thank you for leaving your comment and reaching out. I hope that helps.
– Natasha Tracy
Updating my settings
Natasha, I am a survivor of Bipolar illness. I became depressed at age 16 and didn’t receive any treatment until I was 27 because the cult I lived in didn’t recognize illness or doctors. My father was the leader of the cult. After many different antidepressants, I was diagnosed with bipolar II at age 37. I finally found the right treatments At age 42 and I am now 55.
I write all of this to tell you, I am so very proud of you! My daughter has ultra rapid cycling, my ex husband committed suicide 4 months ago, 2 of my sons have bipolar, PTSD and ADHD. My mom and dad and Grandfather have untreated mental illness. My two sisters and one brother have bipolar illness also.
I’ve never posted here. But I have read your posts diligently along with the Bipolar Hope digital magazine.
You have taught me so very much about this illness and inspired me! I’m naturally gregarious but social anxiety cripples me in a few areas especially if depressive symptoms come on.
I speak out openly, in person and on social media whenever I can about this illness and surviving it. Most of my posts are never commentated on but that is ok. I’m convinced that I’m helping. One very close friend sought out help when her son was diagnosed. One other very close friend suffered in silence when her daughter committed suicide last year. She finally told our friends after six months. I think the pain was too much for her. I understand.
But I’m a loud mouth! I speak up and share your articles, my thoughts, my struggles and research articles.
You truly are inspirational and educate so many people! My thought is if I can help ONE person then I’m grateful!
I’m rambling here. I just wanted to tell you I’m so proud of the way you walk our pathless path! I’m hoping one day I will decide to reach out by blogging or some other form.
I have been in ‘renission’ now for 5 years. That’s not to say I haven’t had mood swings; I have. I am no longer in the confused state I had been in for a long while; the state where you can’t see the mood coming, you don’t know your triggers, you know all about the illness but have no knowledge how to interpret and put into practice a wellness plan.
I see these things now. It’s been through your posts and Bipolar Hope magazine that tremendous growth occurred. I now believe educating oneself is paramount to wellness.
I just want to also mention I read Oprah Winfrey’s book, Super Sundays as a guide to keep me on my path.
I’ve learned with treatment, a support system, and education it is possible to get out of the woods fumbling around and reach a state of taking control of our lives. I’m not saying my sysmptoms have stopped. I’m saying I am well. I hope this is understood.
Anyhow, thank you Natasha! I hope someday researchers see beyond the fact that even though we aren’t cash cows for the pharmaceutical companies there are a very large percent of people still suffering and we need research ramped up. Funny: there has never been ONE medication produced specifically for bipolar illness.
Love and peace
Beth
Hi Beth,
Thank you for your kind words. I love a fellow loudmouth :)
– Natasha Tracy
I suffered from cycling so bad it shifted within minutes. I always rapid-cycled, with a few cycles per year, but it became worse and worse as I approached menopause. Tried everything, nothing worked, and I became suicidal. Then my PCP and Psych suggested a total hysterectomy. Had the surgery (oves and ute removed), and in the recovery room I noticed right away that the cycling had stopped. Not saying this would be the answer for all women, but it worked for me. I had one fabulous year where I did not cycle once. It’s been 2 1/2 years and my rapid cycles are back…but they shift every few weeks/months instead of every few minutes. Hot flashes are nothing compared to the hell of shifting mood from minute to minute.
Hello not sure if your still on this site but can you please describe you mood changes from minute to minute in a day . How did you get diagnosed ?
My Psy Dr and I discussed this ultra rapid cycling issue last week. This is definitely real and I can vouch for it. And you’re right, it sucks big time. I told my Dr. I feel like a human yoyo. Up and down constantly. Were trying to get the mods stabilizers right to help combat this issue and its taking forever.
Hi Adam,
In my experience, getting treatment right always feels like it’s taking forever. Being a human yo-yo, as you said, is exhausting.
– Natasha Tracy
I’m not generally a rapid cycler, let alone ultradian cycler, but I have when antidepressants were involved. Because of that, it finally became evident to my psychiatrist 9 years ago that I would not be prescribed antidepressants any longer. Luckily for me, Seroquel XR has been very helpful for me when I do suffer depressive periods.
As my illness progressed, I did become more apt to having mixed features (formerly known as mixed episodes). However, my mixed features were not of a type where I had stability mixed in. I wasn’t usually rapidly cycling in any way, really, instead I experienced manic and depressive symptoms simultaneously. At the same exact time, or in a way where one dominate episode pretty much remained constant, meeting minimum time requirements and other criteria for a full bipolar episode. I tended to lean more in the manic direction, at least during my hospitalizations. They were often considered “mania with mixed features” according to DSM-5 terminology, though I do believe I have had depression with mixed features” and even “hypomania with mixed features”, again, using DSM-5 terminology. I know that the DSM-5 also has a “with rapid cycling” specifier, but doesn’t seem to have a “with ultradian cycling” specifier. Why that is I’m not sure.