New Treatment Approaches for Treatment-Resistant Depression

Posted by Natasha Tracy | Jun 6, 2012

I have been known to lament that there’s nothing new under the sun when it comes to depression treatment, and thus, there is little hope for people with true treatment-resistant depression. (And by treatment-resistant depression I mean people who really have tried everything, and there are few in this category.)

But I forget how far we’ve come and how fast. It isn’t fair to say there aren’t new approaches to treatment-resistant depression because there are new approaches being researched and approved every year. Here are a few noted by Current Psychiatry article Innovative approaches to treatment-resistant depression:

Breaking Bipolar Reading Round-Up

Posted by Natasha Tracy | Dec 23, 2011

Happy holidays all.

I’m a pretty busy gal right now, so not a lot of time to write new material. I promise I’ll try to get to something new next week.

However, while you’re waiting, have you caught up on all your Breaking Bipolar articles? No? I didn’t think so. Here’s a run-down on some of what I’ve been doing over at HealthyPlace:

Last Minute Holiday Tips for the Bipolar – just published today. Here are four things you should know before you get any deeper into the holidays.
What 2011 Taught us About Mental Illness – a wrap-up of the top ten things research taught us about mental illness last year including: bipolar misdiagnosis, bipolar treatment success predictor, mania treatment comparison and antipsychotic information. Part one and part two.
You’re Narcissistic! Getting Over Insults – How one reader got to me even though I knew they shouldn’t have.
Celebrating Mental Health News – on why we should celebrate the good moments in mental illness.
How to Choose a Good Psychiatrist – one I’ve touched on here but in more detail.
Bipolar Disorder Thought Types – have you ever considered the odd types of thoughts you have a person with a mental illness? I have.
The Importance of Self-Care in Bipolar Disorder – tips on self-care plus a video.
Sexual Health and Bipolar Disorder – the sexual concerns of people with mental illness.

Free rTMS, Brain Changes in Depressed Females, Why Anti-Benzodiazepine? – 3 New Things

Posted by Natasha Tracy | Sep 29, 2011

Last week I didn’t post three new things but don’t take that to mean I wasn’t learning because I certain was, and always am. For this week I have these three new pieces of information to share:

Repetitive transcranial magnetic stimulation (rTMS) treatment for depression to be free for (some) Canadians
Brain changes are noted in depressed females
Why are some doctors anti-benzodiazepine?

Should Ecstasy (MDMA) be a Psychiatric Medication?

Posted by Natasha Tracy | Sep 26, 2011

You may not know this, but ecstasy (MDMA) has been studied as a psychiatric medication. Yes, that’s right, that stuff kids take at raves. The stuff that makes you thirsty and fall in love to the person next to you. That stuff. And MDMA was shown effective in several psychiatric uses.

But research on MDMA (ecstasy) was curtailed in 1985 when the US government named it a class 1 drug (like heroin) over the objections of doctors. Psychiatric research on MDMA is gearing up again though and it has shown promise in treating post-traumatic stress disorder (PTSD) and possibly depression and anxiety.

How to Get Off Antidepressants Effexor/Pristiq (Venlafaxine/Desvenlafaxine)

Posted by Natasha Tracy | Sep 12, 2011

Or other bothersome antidepressants.

Generally, following the rules I wrote about last week on how to stop antidepressants while minimizing withdrawal work, and most people can successfully withdraw from antidepressants with few side effects.

Some Antidepressants Are Hard to Get Off Of

Unfortunately, some antidepressants are not so easy to get off of no matter what you do. Some antidepressants:

Resist a taper strategy
Have intolerable withdrawal effects anyway *

People Have Trouble Withdrawing from these Antidepressants

Any antidepressant can feel impossible to withdraw from, but the antidepressants people have most trouble withdrawing from are:

Paroxetine (Paxil)
Duloxetine (Cymbalta)
Venlafaxine (Effexor, any version)
Desvenlafaxine (Pristiq)

But by far, venlafaxine and desvenlafaxine (Effexor and Pristiq) are the ones I hear about. In my opinion, these two drugs are a nightmare to come off of for most people. ^ (I’m not saying everyone has trouble with these antidepressants, just that many do.)

Here are tips on how to get off of horrible~ drugs like venlafaxine (Effexor) and desvenlafaxine (Pristiq).

Depressed People Who Take Antidepressants Do Better Long-Term – Part 2

Posted by Natasha Tracy | May 16, 2011

As I mentioned last week, it’s very difficult to measure long-term outcomes of depression treatment due to the confounding depression variables like severity of depression, duration of depression, number of depressions and so on.

In short, the sicker you are, the more depressed you are, the more likely it is you’ll get treatment.

Antidepressant Treatment Outcomes Long-Term, A Study

I discussed the basic outcomes of this study: The association between antidepressant use and depression eight years later: A national cohort study by Colman et al. which tries to take these variables into account.

Colman et al. showed those who took antidepressants had better depression treatment outcomes than those who didn’t, eight years later, once confounding variables were taken into consideration.

I’ll now point out the strengths and weaknesses of this study as well as some other interesting tidbits shown or cited in the study. Oh, and I’ll give my opinion on what it all means.

What You Should Eat When Taking Geodon – Food and Geodon

Posted by Natasha Tracy | Apr 3, 2011

Long (long) time readers will recall that once-upon-a-time I took the atypical antipsychotic Geodon. I found this to be an unbearably painful and side effect laden psych med. I hated Geodon. I wouldn’t wish Geodon on my worst enemy. I lost touch with reality with Geodon. I passed out at work on Geodon. I got sick constantly on Geodon.

You know, that being said, Geodon works for a lot of people.

I gather my reaction to this antipsychotic was fairly atypical. And if I had known what to eat when taking Geodon that might have helped.

Low Dose Antipsychotics – Do They Help?

Posted by Natasha Tracy | Oct 13, 2010

I am very medication-reactive. Not so much with the positive effects, but I can almost guarantee you I’ll get all the side effects.I get every side effect for antidepressants, every side effect for antipsychotics and every side effect for pretty much anything else.

And sometimes, just for good measure, I’ll get side effects that doctors say “aren’t possible”. They are my favorite. And those overractions are often on the lowest known effective dose of the medication.

But if you add a low dose, lower than thought effective, of an antipsychotic, can this be helpful?

Everything You Wanted to Know About Seroquel But Were Afraid to Ask

Posted by Natasha Tracy | Aug 19, 2010

There is so much to know about Seroquel, and really, you’re so right to be afraid.

Over the last week-and-a-half I’ve been writing at HealthyPlace about the full prescribing information for Seroquel. I’ve done this to make a point – the full prescribing information for Seroquel or any drug is a treasure trove of knowledge. The full prescribing information really let’s you know what you’re getting into bed with and in the case of Seroquel, you’re getting into bed with a very dangerous substance. (That’s OK. I mean really, the only people worth getting into bed with are dangerous.) And whenever you take a (psychotropic, psychiatric) medication it’s worth knowing the risks. Seriously. Like, really worth it. And the risks of taking a medication are laid out in black and white in the prescribing information.

Antipsychotic Seroquel Information

I discuss Seroquel prescribing information section by section:

Part I: Drug stats and Seroquel warnings, dosage and indications

Part II: Seroquel warnings and precautions

Part III: Seroquel side-effects (adverse reactions)

And just to be clear, I’m not attacking Seroquel here. Seroquel just happens to be the highest grossing psychotropic medication and that’s why I picked it. Prescribing information and all its nastiness is available for any drug. I do think though, particularly everyone on an antipsychotic should look at its full prescribing information. I’m not suggesting these are bad medications, but what I am suggesting is that they are very dangerous and you need to be made aware of it before you stay on them for years.